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Bcl-2 Monoclonal Antibody (100/D5)
- 类型：一抗
- 品牌：Thermo Fisher
- 种属：Mouse,Human应用：WB,ICC/IF,IHC(P)抗体亚型：IgG1, kappa偶联物：Purified宿主：Mouse克隆号：100/D5浓度：0.2 mg/mL
规格: 500 µL
货号: MA511757
价格: ¥5144.00
优惠: ¥3600.00
应用 |
建议稀释比 |
|
|
免疫印迹 (WB) |
1:50-1:200 |
|
|
免疫组化（石蜡） (IHC (P)) |
1:50-1:100 |
|
|
免疫细胞化学 (ICC/IF) |
1:10-1:100 |
|
|
流式细胞分析 (Flow) |
0.5-1 µg/test |
|
产品详细信息
MA5-11757 targets BCL-2 in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human and mouse samples.
The MA5-11757 immunogen is a synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein.
靶标信息
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.