相册共1张
点击图片可以查看相册
KDEL Polyclonal Antibody, Alexa Fluor™ 555
- 类型：一抗
- 品牌：Thermo Fisher
- 种属：Mouse,Rat,Human,Hamster应用：ICC/IF抗体亚型：IgG偶联物：Alexa Fluor 555/AF555宿主：Rabbit浓度：1 mg/mL
规格: 50μg
货号: PA1013A555
价格: ¥4315.00
优惠: ¥3021.00
应用 |
建议稀释比 |
|
|
免疫细胞化学 (ICC/IF) |
1-10 µg/mL | |
产品详细信息
PA1013A555 detects KDEL from human, rat, mouse and hamster.
The PA1013A555 immunogen is a synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94.
靶标信息
The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.